Life | Free Full-Text | Origin of the Reductive .
We initially examine the energetics of pyruvate synthesis using ethylthioacetate (ETA) as a prebiotic counterpart of acetyl-CoA to clarify the environmental condition necessary for it to be driven thermodynamically. Figure 2 shows the calculated Eh-pH relationship of the pyruvate formation (ETA + CO 2 + H + + 2e − → pyruvate + ethanethiol (EtSH)), together with those of the H 2 /H +, H 2 S ...